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BETA-2, CONNEXIN
Descriptors Found:
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DeCS
Descriptor
English
:
Connexin 26
Descriptor
Spanish
:
Conexina 26
Descriptor
Portuguese
:
Conexina 26
Synonyms
English
:
Connexin Cx26
Connexin beta-2
Gap Junction beta-2 protein
beta2 Connexin
26, Connexin
Connexin beta 2
Connexin, beta2
Cx26, Connexin
Gap Junction beta 2 protein
beta-2, Connexin
Tree Number:
D12.776.543.585.250.100
Definition
English
:
A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the
cochlea
and
epidermis
, its hexamers form channels between cells that open to allow cell-to-cell
diffusion
of small molecules as well as
recycling
of
potassium
.
Mutations
in
Connexin 26
are associated with congenital SENSORINEURAL
HEARING LOSS.
History Note
English
:
2017 (1993)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56638
Unique Identifier:
D000072259
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS